CXCR6 Rabbit anti-Human, Polyclonal, Invitrogen™
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA112536
A suggested positive control for this product is SW1353 cell lysate.Human Immunodeficiency Virus (HIV) and Simian Immunodeficiency Virus (SIV) require coreceptors to enter and infect target cells. They are dependent upon an interaction between the viral envelope glycoprotein with T-cell antigen T4 (CD4) and a G-protein coupled receptor (GPCR). HIV-1 infection relies upon interaction with a chemokine receptor, usually chemokine (C-C) receptor 5 (CCR5). During progression of the infection, the virus tends to rely upon chemokine (C - X - C) receptor 4 (CXCR4). SIV also utilizes CCR5 in the early stages of infection, but during progression it tends to rely on two orphan GPCR′s named chemokine (C-X-C) receptor 6 (Bonzo) and G-protein coupled receptor 15 (BOB/GRP15). Bonzo mRNA expression has been localized to lymphoid tissues and activated peripheral blood lymphocytes.
|PBS with 0.02% sodium azide|
|Chemokine C-X-C Motif Receptor 6, CXCR6, STRL33, TYMSTR|
|-20° C, Avoid Freeze/Thaw Cycles|
|Synthetic peptide corresponding to residues 319-338 of human Bonzo.|
|Antigen affinity chromatography|
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