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CXCR6 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA112537

Catalog No. 01-674-197


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Description

Description

A suggested positive control for this product is human spleen lysate.

Human Immunodeficiency Virus (HIV) and Simian Immunodeficiency Virus (SIV) require coreceptors to enter and infect target cells. They are dependent upon an interaction between the viral envelope glycoprotein with T-cell antigen T4 (CD4) and a G-protein coupled receptor (GPCR). HIV-1 infection relies upon interaction with a chemokine receptor, usually chemokine (C-C) receptor 5 (CCR5). During progression of the infection, the virus tends to rely upon chemokine (C - X - C) receptor 4 (CXCR4). SIV also utilizes CCR5 in the early stages of infection, but during progression it tends to rely on two orphan GPCR ft.s named chemokine (C-X-C) receptor 6 (Bonzo) and G-protein coupled receptor 15 (BOB/GRP15). Bonzo mRNA expression has been localized to lymphoid tissues and activated peripheral blood lymphocytes.
Specifications

Specifications

CXCR6
Polyclonal
PBS with 0.02% sodium azide
O00574
Chemokine C-X-C Motif Receptor 6, CXCR6, STRL33, TYMSTR
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
10663
Western Blot
Unconjugated
CXCR6
Liquid
CXCR6
Synthetic peptide corresponding to residues 11-25 of human Bonzo.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Documents
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