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Cyclin A Mouse anti-Human, Unlabeled, Clone: 25, BD

Mouse Monoclonal Antibody

$226.00 - $421.00

Specifications

Antigen Cyclin A
Isotype IgG1
Immunogen Human Cyclin A aa. 26-144
Formulation Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Conjugate Unconjugated
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Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
BDB611268
View Documents
BD Biosciences
611268
50μg
Each for $226.00
Add to cart
 
BDB611269
View Documents
BD Biosciences
611269
150μg
Each for $421.00
Add to cart
 
Description

Description

Progression of the mammalian cell cycle is regulated by phosphorylation of many key proteins. Several classes of cyclins (A-E) act as regulatory subunits for cyclin-dependent kinases (cdks). These cyclin-cdk holoenzymes are essential for proper control of cell cycle progression. They phosphorylate and regulate a variety of substrates whose activity is required for cell cycle transitions. The temporal expression of cyclins is tightly regulated throughout the cell cycle by synthesis and degradation. Such regulation plays a critical role in controlling the enzymatic activity of the cdks. Cyclin A, one of the mitotic cyclins, activates Cdk2 near the start of S phase and is necessary for the initiation of DNA replication. In mammalian somatic cells, Cyclin A is required during S phase and passage through G2. The D and E type cyclins regulate passage through G1, while Cyclin B is a critical regulator of mitosis. It has been shown in a number of species that mutation or disruption of normal Cyclin A expression causes cells to arrest at G2. Cyclin A binds both the cdc2 (Cdk1) and Cdk2 kinases and may also have a role in mitotic dependence on S phase completion.

Host Species: Mouse
Clone: 25
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human Cyclin A aa. 26-144
Formula Weight [Chemical]: 60kDa

Bioimaging, Immunofluorescence, Western Blotting

Specifications

Specifications

Cyclin A
Human Cyclin A aa. 26-144
Unconjugated
Cell Biology
Mouse
Affinity Purified
Monoclonal
Store undiluted at -20°C.
IgG1
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Primary
Western Blot
RUO
25
250μg/mL
SDS
Product Certifications

For Research Use Only.

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