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Cyclophilin B Rabbit anti-Canine, Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA1027A

Catalog No. PA1027A


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Description

Description

PA1-027A detects cyclophilin B (CyPB) in mouse, rat, canine, and human tissues. PA1-027A has been successfully used in Western blot procedures, IF/ICC and IHC (P). By Western blot, this antibody detects a ~19 kDa protein representing CyPB from rat liver extract. The PA1-027A immunogen is a synthetic peptide corresponding to residues C(194) G K I E V E K P F A I A K E(208) of human CyPB. This sequence is almost completely conserved between human, mouse, rat, bovine, and chicken. PA1-027A immunizing peptide (Cat. No. PEP-058) is available for use in neutralization and control experiments.

Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) or FK506. Proteins which bind FK506 are termed FK506 Binding Proteins (FKBP ft.s) and those which bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation. Thus, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase ft.s, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins.
Specifications

Specifications

Cyclophilin B
Polyclonal
Unconjugated
PPIB
Liquid
PPIB
Synthetic peptide corresponding to residues C(194) G K I E V E K P F A I A K E(208) of human CyPB.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Canine, Human, Mouse, Rat
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
PBS with 1mg/mL BSA and 0.05% sodium azide
P23284, P24369, P24368
Cyp B, Peptidyl-prolyl cis-trans isomerase B, EC 5.2.1.8, PPIase, Rotamase, S-cyclophilin, SCYLP, CYP-S1
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
19035, 478337, 5479, 64367
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