anti-CYP3A4, MaxPab™ Polyclonal, Abnova

Rabbit Polyclonal

Manufacturer: Abnova Corporation H00001576B01P

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Catalog No. 89-018-884

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    Antigen cytochrome P450, family 3, subfamily A, polypeptide 4
    Conjugate Unlabeled
    Cross Reactivity Human
    Format Affinity Purified
    Host Species Mouse
    Immunogen CYP3A4 (AAI01632.1, 1 a.a. ∽503 a.a) full-length human protein.
    Purification Method Protein A column
    Quantity 50μg
    Regulatory Status RUO
    Research Discipline Endocrine/Metabolism
    Primary or Secondary Primary
    Monoclonal or Polyclonal Polyclonal

    This gene, CYP3A4, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs which are are used today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4.

    Host Species: Rabbit
    Species Reactivity [for Features Main]: Human
    Immunogen: CYP3A4 (AAI01632.1, 1 a.a. ~ 503 a.a) full-length human protein.

    Detection Antibody, Immunohistochemistry (Paraffin), Western Blotting

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