Cyp46a1 Rabbit anti-Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA528207
PA5-28207 targets CYP46A1 in WB applications and shows reactivity with mouse samples. The PA5-28207 immunogen is recombit fragment corresponding to a region within amino acids 63 and 371 of Human CYP46A1. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism.
|Recombit fragment corresponding to a region within amino acids 63 and 371 of Human CYP46A1|
|Antigen affinity chromatography|
|0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7|
|CP46, CYP46, CH24H, cholesterol 24-hydroxylase, cytochrome P450 46A1, cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase)|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
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