CYP1A2 Mouse anti-Human, Non-human primate, Clone: 3B8C1, Invitrogen™
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA3037
MA3-037 detects Cytochrome P450 1A2 from human and non-human primate samples. MA3-037 has been successfully used in Western blot, immunocytochemistry and immunofluorescence applications. By Western blot, this antibody detects a ∽58 kDa band representing Cytochrome P450 1A2. The MA3-037 immunogen is rat cytochrome P450 protein.This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme′s endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3′ untranslated region.
|Rat cytochrome P450 protein.|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|ascites with 0.05% sodium azide|
|CP12, P3-450, P450(PA)|
|Human, Non-human Primate|
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