CYP3A4/CYP3A5 Mouse anti-Bovine, Human, Clone: F24 P2 B10, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA3032
MA3-032 detects Cytochrome P450 3A4/3A5 from human cell line HepG2, and from bovine liver and pancreas samples. MA3-032 has been successfully used in Western blot applications. By Western blot, this antibody detects a ~54 kDa band representing Cytochrome P450 3A4/3A5. The MA3-032 immunogen is a synthetic peptide corresponding to residues E S R D G T V S G A, conjugated to ovalbumin.This gene,CYP3A5, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. The enzyme metabolizes drugs such as nifedipine and cyclosporine as well as the steroid hormones testosterone, progesterone and androstenedione. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. This cluster includes a pseudogene, CYP3A5P1, which is very similar to CYP3A5. This similarity has caused some difficulty in determining whether cloned sequences represent the gene or the pseudogene.
|Synthetic peptide corresponding to residues E S R D G T V S G A, conjugated to ovalbumin.|
|-20° C, Avoid Freeze/Thaw Cycles|
|1576, 1577, 282214, 507988|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|F24 P2 B10|
|ascites with 0.05% sodium azide|
|CYP3A4, CYP3A5, CP35, P450PCN3, PCN3|
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