Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

CYP3A4 Rabbit anti-Human, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA1343

Catalog No. PA1343


Add to cart

Description

Description

PA1-343 detects cytochrome P450 (P450) 3A4 from human and rat tissues and cells. This antibody detects, to a lesser extent, other P450 isoforms. PA1-343 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~46 kDa protein representing P450 3A4 from rat liver extracts. The PA1-343 immunogen is purified, His-tagged, full length human P450 3A4 fusion protein.

The cytochrome P450 (P450) superfamily of enzymes is one of three enzyme systems which metabolize the fatty acid arachadonic acid (AA) to regulators of vascular tone. P450 enzymes are monooxygenase enzymes which require several co-factors such as nicotinamide adenine dinucleotide phosphate (NADPH) and P450 reductase. There are over 200 known genes which encode P450s. Epoxygenases are those P450s which metabolize AA to epoxyeicosatrienoic acid (EETs) and omega-hydroxylases are those P450s which produce 19- and 20-hydroxyeicosatetraenoic acids (19- and 20-HETE). As well as fatty acid metabolism, P450s also metabolize many drugs and toxins. Cytochrome P450 3A4 is abundantly expressed in liver and small intestine and is inducible by barbiturates, glucocorticoids and rifampicin.
Specifications

Specifications

CYP3A4
Polyclonal
PBS with 1mg/mL BSA and 0.05% sodium azide
P08684
CYP, P450, Quinine 3-monooxygenase, CYPIIIA4, Nifedipine oxidase, Taurochenodeoxycholate 6-alpha-hydroxylase, NF-25, P450-PCN1
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
1576
Western Blot
Unconjugated
CYP3A4
Liquid
CYP3A4
Purified, His-tagged, full length human P450 3A4 fusion protein.
Ammonium sulfate precipitation
RUO
Antibody
Polyclonal
Human, Rat
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit