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Cytokeratin 18 Mouse anti-Mammalia, Clone: C-04, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA119039

Catalog No. 01-675-012


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Description

Description

Perform Western blot under non-reducing conditions.

Cytokeratin 18 (Keratin 18, KRT18, type I cytoskeletal 18) belongs to the type A (acidic) subfamily of low molecular weight keratins, exists in combination with cytokeratin 8. Tissues from gastrointestinal tract, respiratory tract and urogenital tract, as well as endocrine and exocrine tissues and mesothelial cells are positive for cytokeratin 18. Further, cytokeratin 18 is found primarily in non-squamous epithelia and is present in a majority of adenocarcinomas and ductal carcinomas, but not in squamous cell carcinomas. Hepatocellular carcinomas express only cytokeratins 8 and 18. Mutations in the cytokeratin 18 gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for the cytokeratin 18 gene. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial maligcies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays.
Specifications

Specifications

Cytokeratin 18
Monoclonal
1 mg/mL
PBS with 15mM sodium azide; pH 7.4
P05783, P05784, Q5BJY9
CK-18, Keratin-18, K18, Cytokeratin endo B, Keratin D
Mouse
IgG1
100 μg
4° C, do not freeze
Primary
16668, 294853, 3875
ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
C-04
Unconjugated
KRT18
Liquid
KRT18
Cytoskeleton preparation of epidermal carcinoma cell line A431.
Protein A
RUO
Antibody
Monoclonal
Mammalia
Documents
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