Cytokeratin 18 Sheep anti-Human, Polyclonal, Invitrogen
Sheep Polyclonal Antibody
Manufacturer: Invitrogen PA175097
PA1-75097 specifically detects Cytokeratin-18. PA1-75097 has been successfully used in ELISA applications. The PA1-75097 immunogen is Recombit CK18.Cytokeratin 18 (Keratin 18, KRT18, type I cytoskeletal 18) belongs to the type A (acidic) subfamily of low molecular weight keratins, exists in combination with cytokeratin 8. Tissues from gastrointestinal tract, respiratory tract and urogenital tract, as well as endocrine and exocrine tissues and mesothelial cells are positive for cytokeratin 18. Further, cytokeratin 18 is found primarily in non-squamous epithelia and is present in a majority of adenocarcinomas and ductal carcinomas, but not in squamous cell carcinomas. Hepatocellular carcinomas express only cytokeratins 8 and 18. Mutations in the cytokeratin 18 gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for the cytokeratin 18 gene. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial maligcies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays.
|PBS with 0.09% sodium azide|
|-20° C, Avoid Freeze/Thaw Cycles|
|Recombit human CK18|
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