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Cytokeratin 5/14 Mouse anti-Human, Clone: 16.4, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA112590

Catalog No. 01-674-358


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Description

Description

Cytokeratins(CK) are intermediate filaments of epithelial cells, both in keratinizing tissue (ie. Skin) and non-keratinizing cells (ie. Mesothelial cells). Although not a traditional marker for endothelial cells, cytokeratins have also been found in some microvascular endothelial cells. Atleast 20 different CKs in the molecular range of 40-70 k Da and isoelectric points of 5-805 can be identified using two dimensional gel electrophoresis. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells. Monoclonal antibodies to cytokeratin proteins can be useful markers for tumor identification and classification.Belonging to the type A (acidic) subfamily of low molecular weight keratins and existing in combination with keratin 5, keratin 14 distinguishes stratified epithelial cells from simple epithelial cells and is useful in identification of squamous cell carcinomas. It is considered a prognostic marker in breast carcinomas.

Specifications

Specifications

Cytokeratin 5/14
Monoclonal
0.54 mg/mL
PBS with 0.08% sodium azide
P02533, P13647
Keratin type II cytoskeletal 5, 58 kDa cytokeratin, Cytokeratin-5, CK-5, Keratin-5, K5, Type-II keratin Kb5, KRT5, Keratin type I cytoskeletal 14, Cytokeratin-14, CK-14, Keratin-14, K14, KRT14
Mouse
IgG2a
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
3852, 3861
Immunohistochemistry (Frozen), Western Blot
16.4
Unconjugated
KRT5
Liquid
KRT14, KRT5
Cytokeratin enriched extract of feline tongue epithelium.
Protein A/G
RUO
Antibody
Monoclonal
Human
Documents
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