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Cytokeratin Pan Type II Mouse anti-Human, Clone: AE3, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA15762

Catalog No. 01-675-181


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Description

Description

MA1-5762 reacts with all basic (type II) human keratins in human samples, including K1, K2, K3, K4, K5, K6, K7 and K8. MA1-5762 has been successfully used in Western blot, immunohistochemistry and electron microscopy procedures. The MA1-5762 immunogen is human epidermal keratins.

Cytokeratin pan is part of a subfamily of intermediate filament proteins that are characterized by remarkable biochemical diversity, and represented in human epithelial tissues by at least 20 different polypeptides. Cytokeratins range in molecular weight between 40 kDa- 68 kDa, and an isoelectric pH between 4.9-7.8. The individual human cytokeratins are numbered 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial maligcies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays. The composition of cytokeratin pairs vary with the epithelial cell type, stage of differentiation, cellular growth environment, and disease state. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.
Specifications

Specifications

Cytokeratin Pan Type II
Monoclonal
Unconjugated
KRT1
Liquid
KRT1, KRT2, KRT3, KRT4, KRT5, KRT6A, KRT7, KRT72, KRT8
Human epidermal keratins from P3 x 63 Ag8 cells
Protein G
RUO
Antibody
Monoclonal
Human
Immunohistochemistry (Paraffin), Immunomicroscopy, Western Blot
AE3
PBS with 0.1% sodium azide
P02538, P04264, P05787, P08729, P12035, P13647, P19013, P35908, Q14CN4
HMWCK, pankeratin
Mouse
IgG1
200 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
140807, 3848, 3849, 3850, 3851, 3852, 3853, 3855, 3856
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