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D4-GDI Mouse anti-Human, Clone: 10D774, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA141181

Catalog No. 01-676-587


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Description

Description

D4-GDI (GDP dissociation inhibitor) is a negative regulator of the ras-related Rho family of GTPases. Since the Rho GTPases promote cytoskeletal and membrane changes associated with apoptotic cell death, the removal of the D4-GDI block through its cleavage is important for inducing apoptosis. Caspase-3 cleaves the 28 kD mature form of D4-GDI to give a 23 kD and 5 kD size fragment. The 23 kD fragment then translocates to the nucleus. The mechanisms involving cleavage of D4-GDI with apoptosis are not presently known. Activation of the Jun N-terminal kinase, a regulator of apoptosis, may be one of the mechanisms.

Suggested positive control: antigen standard for ARHGDIB (transient overexpression lysate), Daudi or Jurkat.
Specifications

Specifications

D4-GDI
Monoclonal
Unconjugated
ARHGDIB
Liquid
ARHGDIB
Synthetic peptide corresponding to a portion of human D4-GDI.
Protein G
RUO
Antibody
Monoclonal
Human
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Western Blot
10D774
PBS with 0.02% gelatin and 0.02% sodium azide
P52566
D4, GDIA2, GDID4, LYGDI, Ly-GDI, RAP1GN1, RhoGDI2
Mouse
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
397
Documents
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