DAB1 Sheep anti-Mouse, Polyclonal, Invitrogen
Sheep Polyclonal Antibody
Manufacturer: Invitrogen PA112425
A suggested positive control for this product is 293 cells transfected with Dab-1 HA tag.Disruption of Dab1 results in aberrant migration of neurons during development and disorganization of laminar structures throughout the brain. Dab1 is thought to function as an adaptor molecule in signal transduction processes. It contains a protein-protein interaction (PI) similar to the phosphotyrosine binding domain of the Shc oncoprotein, it is phosphorylated by the Src protein tyrosine kinase, and it binds to SH2 binding domains in a phosphotyrosine dependent manner. DAB1 acts downstream of reelin in a signalling pathway.
|PBS with 0.08% sodium azide|
|RP23-356E21.1, AI956902, C630028C02Rik, scm, scr, scrambler, yot|
|-20° C, Avoid Freeze/Thaw Cycles|
|residues 1-179 of mouse disabled coupled to a GST fusion protein.|
|Ammonium sulfate precipitation|
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