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DACT2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520629

Catalog No. PIPA520629


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Description

Description

A suggested positive control is SK-N-SH cell lysate. PA5-20629 can be used with blocking peptide PEP-0749.

The Wnt signaling cascade is a conserved process in multicellular animals that plays important roles during development and can contribute to cancer and other diseases. Many members of this pathway are also expressed in the postnatal tissues such as brain. One such protein is Dact2, a member of the Dact protein family that was initially identified through binding to Disheveled (Dvl), a cytoplasmic protein essential to Wnt signaling. Dact2 is most prominent during the development of the thymus kidneys, and salivary gland. Dact2 is thought to play a role distinct from that of Dact1 with Dact2 having a greater impact on a beta-catenin-independent process termed planar cell polarity/convergent-extension signaling. Furthermore, Dact2 but not Dact1 can inhibit Nodal signaling by promoting the endocytic degradation of TGF-beta receptors. At least two isoforms of Dact2 are known to exist.
Specifications

Specifications

Dact2
Polyclonal
Unconjugated
DACT2
Liquid
DACT2
a 12 amino acid peptide from near the amino terminus of human DACT2.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q5SW24, Q7TN08
PP13671, C6orf116, DAPPER2, DPR2, RP11-503C24.7, bA503C24.7; dapper homolog 2; dapper homolog 2, antagonist of beta-catenin
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
168002, 240025, 308212
Documents
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