DACT2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520629
A suggested positive control is SK-N-SH cell lysate. PA5-20629 can be used with blocking peptide PEP-0749.The Wnt signaling cascade is a conserved process in multicellular animals that plays important roles during development and can contribute to cancer and other diseases. Many members of this pathway are also expressed in the postnatal tissues such as brain. One such protein is Dact2, a member of the Dact protein family that was initially identified through binding to Disheveled (Dvl), a cytoplasmic protein essential to Wnt signaling. Dact2 is most prominent during the development of the thymus kidneys, and salivary gland. Dact2 is thought to play a role distinct from that of Dact1 with Dact2 having a greater impact on a beta-catenin-independent process termed planar cell polarity/convergent-extension signaling. Furthermore, Dact2 but not Dact1 can inhibit Nodal signaling by promoting the endocytic degradation of TGF-beta receptors. At least two isoforms of Dact2 are known to exist.
|a 12 amino acid peptide from near the amino terminus of human DACT2.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|PP13671, C6orf116, DAPPER2, DPR2, RP11-503C24.7, bA503C24.7; dapper homolog 2; dapper homolog 2, antagonist of beta-catenin|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|168002, 240025, 308212|
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