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DAP3 Mouse anti-Human, Mouse, Clone: 42C617.1.2, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA141279

Catalog No. 01-676-609


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Description

Description

This sequence is 75% homologous in mouse and rat. Suggested positive control: Jurkat, antigen standard for DAP3 (transient overexpression lysate), Jurkat whole cell lysate.

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Recently, five novel apoptotic genes (named DAP genes for: Death Associated Proteins) have been identified that code for proteins, which display a diverse spectrum of biochemical activities. These include a novel type of calcium/calmodulin-regulated kinase which carries ankyrin repeats and a death domain (DAP-kinase), a nucleotide-binding protein (DAP-3), a small proline-rich cytoplasmic protein (DAP-1), and a novel homolog of the eIF4G translation initiation factor (DAP-5) (1). DAP-3 has an ATP/GTP binding motive (P-loop) and has been isolated from human and mouse, and named as hDAP-3 and mDAP-3 (Death Associated Protein-3), respectively (2-3). Sequence analysis revealed an 82% amino acid identity between human and mouse protein. In situ hybridization and northern blot analysis showed an abundant mRNA expression with a pronounced expression in highly proliferative epithelial compartments. Overexpression of DAP-3 leads to cytochrome c release and induction of cell death. DAP-3 mediated apoptosis was shown to depend on a functional P-loop. mDAP-3 is localized to the mitochondrial matrix and in contrast to cytochrome c, retained its mitochondrial localization during apoptosis induction (3).
Specifications

Specifications

DAP3
Monoclonal
0.5 mg/mL
PBS with 0.2% gelatin and 0.05% sodium azide
P51398, Q9ER88
DAP-3, DKFZp686G12159, MGC126058, MGC126059, MRP-S29, MRPS29, bMRP-10
Mouse
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
65111, 7818
Western Blot
42C617.1.2
Unconjugated
DAP3
Liquid
DAP3
Human DAP-3 protein.
Protein G
RUO
Antibody
Monoclonal
Human, Mouse
Documents
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