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DAPK2 Goat anti-Human, Mouse, Polyclonal, Invitrogen™

Goat Polyclonal Antibody

Manufacturer:  Invitrogen PA19035

Catalog No. 01-674-619


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Description

Description

This antibody is predicted to react with canine, porcine and rat based on sequence homology.

Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as RIP and DAP kinase, are mediators of apoptosis. DAP kinase (DAPK) is pro-apoptopic calcium-regulated serine/threonine kinase containing death domain. Ectopic expression of DAPK induces cell death and suppresses oncogenic transformation. DAPK mediates IFN-gamma induced apoptosis. A novel DAP kinase-related protein was recently identified and designated DAPK2 and DRP-1. Ectopicly expressed DAPK2 induced apoptosis in various types of cells. DAPK has high sequence homology to ZIP kinase and DRAK1/2, and they represent a novel family of serine/threonine kinases, which mediates apoptosis through their catalytic activities. The messenger RNA of DAPK2 is expressed in multiple human tissues.
Specifications

Specifications

DAPK2
Polyclonal
Unconjugated
DAPK2
Liquid
DAPK2
Synthetic peptide corresponding to the C terminus amino acids KALHPRRRSSTS.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunohistochemistry, Western Blot
0.5 mg/mL
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Q9UIK4, Q8VDF3
Death-associated protein kinase 2, DRP-1
Goat
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
13143, 23604
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