DAPK2 Goat anti-Human, Mouse, Polyclonal, Invitrogen
Goat Polyclonal Antibody
Manufacturer: Invitrogen PA19035
This antibody is predicted to react with canine, porcine and rat based on sequence homology.Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as RIP and DAP kinase, are mediators of apoptosis. DAP kinase (DAPK) is pro-apoptopic calcium-regulated serine/threonine kinase containing death domain. Ectopic expression of DAPK induces cell death and suppresses oncogenic transformation. DAPK mediates IFN-gamma induced apoptosis. A novel DAP kinase-related protein was recently identified and designated DAPK2 and DRP-1. Ectopicly expressed DAPK2 induced apoptosis in various types of cells. DAPK has high sequence homology to ZIP kinase and DRAK1/2, and they represent a novel family of serine/threonine kinases, which mediates apoptosis through their catalytic activities. The messenger RNA of DAPK2 is expressed in multiple human tissues.
|Synthetic peptide corresponding to the C terminus amino acids KALHPRRRSSTS.|
|Antigen affinity chromatography|
|Immunohistochemistry, Western Blot|
|TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3|
|Death-associated protein kinase 2, DRP-1|
|-20° C, Avoid Freeze/Thaw Cycles|
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