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DAPK2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA519961

Catalog No. PIPA519961


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Description

Description

This antibody will not cross-react with DAPK1. In Western blot applications, this antibody detects a band at ~42kDa. A suggested positive control is A431 cell lysate. PA5-19961 can be used with blocking peptide PEP-0086.

Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as RIP and DAP kinase, are mediators of apoptosis. DAP kinase (DAPK) is pro-apoptotic calcium-regulated serine/threonine kinase containing death domain. Ectopic expression of DAPK induces cell death and suppresses oncogenic transformation. DAPK mediates IFN-gamma induced apoptosis. A novel DAP kinase-related protein was recently identified and designated DAPK2 and DRP-1. Ectopicly expressed DAPK2 induced apoptosis in various types of cells. DAPK has high sequence homology to ZIP kinase and DRAK1/2, and they represent a novel family of serine/threonine kinases, which mediates apoptosis through their catalytic activities. The messenger RNA of DAPK2 is expressed in multiple human tissues.
Specifications

Specifications

DAPK2
Polyclonal
PBS with 0.02% sodium azide
Q9UIK4, Q8VDF3
DRP-1, DRP1; DAP kinase 2; DAP-kinase-related protein 1 beta isoform
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
13143, 23604, 300799
Immunohistochemistry, Western Blot
Unconjugated
DAPK2
Liquid
DAPK2
A peptide corresponding to amino acids near the carboxy terminus of human DAPK2
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
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