DARC Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520360
A suggested positive control is PC-3 cell lysate. PA5-20360 can be used with blocking peptide PEP-0585.DARC, also known as the Duffy antigen/chemokine receptor, is a seven-transmembrane protein homologous to the classical chemokine G-protein coupled receptors (GPCRs) with the exception of the motif required for G protein coupling. DARC can bind with high affinity several chemokines without transducing any signal, suggesting it may modulate the signals normally induced by these chemokines. Recently, DARC was found to interact with KAI1, a four transmembrane protein recently identified as a tumor metastasis suppressor protein. It is thought that tumor cells dislodged from the primary tumor and expressing KAI1 interact with DARC proteins expressed on vascular cells, transmitting a senescent signal to the tumor cells, while tumor cells that have lost KAI1 expression can proliferate and potentially give rise to metastases. At least three isoforms of DARC are known to exist.
|An 18 amino acid peptide from near the amino terminus of human DARC.|
|Antigen affinity chromatography|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|CTA-134P22.3, CCBP1, CD234, Dfy, FY, GPD, GpFy, WBCQ1; Duffy antigen/chemokine receptor; Duffy blood group antigen; Fy glycoprotein; glycoprotein D; plasmodium vivax receptor|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
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