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DAXX Mouse anti-Human, Clone: DAXX-01, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA119296

Catalog No. 01-676-052


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Description

Description

Daxx is an apoptosis-modulating death domain-associated protein with functions in transcriptional regulation. Daxx functions bot in cytoplasm, where it interacts with Fas, and in nucleus (residing in PML oncogenic domains), where it is involved in SUMO-dependent regulation of transcription and subnuclear compartmentalization. Daxx senzitizes the cells to apoptosis, but on the other hand, this protein may also serve in preventing apoptosis in the early embryo. Even regarding the transcription, Daxx can serve both as a corepressor and a coactivator. During ischemic stress, Daxx translocates from the nucleus to the cytoplasm, where in regulates sodium hydrogen exchanger isoform 1 (NHE1).
Specifications

Specifications

DAXX
Monoclonal
Unconjugated
DAXX
Liquid
DAXX
Recombit C-terminal part (aa 558-740) of human Daxx.
Protein A
RUO
Antibody
Monoclonal
Human
Immunocytochemistry, Immunofluorescence, Western Blot
DAXX-01
PBS with 15mM sodium azide; pH 7.4
Q9UER7
Death domain-associated protein 6, Fas death domain-associated protein, ETS1-associated protein 1, EAP1
Mouse
IgG1
100 μg
4° C, do not freeze
Primary
1616
Documents
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