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DBP2 Mouse, Unlabeled, Clone: 24, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611316

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Catalog No. BDB611316


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Description

Description

Splicing, the removal of introns from pre-mRNA, is mediated by spliceosomal complexes and occurs in two distinct catalytic steps. The first step involves cleavage of the 5 ft. exon and the production of a lariat intermediate. In the second step, the 3 ft.-splice site is cleaved and the exons are fused with the concomitant release of the intron lariat. The splicing process involves several conformational rearrangements of the spliceosome that are catalyzed by members of the DEAD/H-box superfamily of RNA helicases. Helicases induce unwinding of double-stranded DNA and RNA in metabolic processes. In S. cerevisiae, helicase proteins that contain the typical superfamily II DEAD/H-box are splicing factors. DBP1 and DBP2 (DEAH-box protein) are putative human helicases and members of the DEAH-box helicase family. DBP2 is expressed in a wide range of human tissues with highest expression in heart, skeletal muscle, and testis. In HeLa cells, DBP2 localizes to the nucleus. In addition, DBP2 is a functional homolog of the S. pombe Cdc28/Prp8 protein which is critical for mitosis. Thus, DBP2 is a putative RNA helicase that is thought to be important in pre-mRNA splicing and cell cycle progression.

Host Species: Mouse
Clone: 24
Isotype: IgG1
Species Reactivity: Human
Immunogen: Human DBP2 aa. 256-366
Formula Weight [Chemical]: 119kDa

Immunofluorescence, Western Blotting

Specifications

Specifications

DBP2
24
Unconjugated
Murine
IgG1
RUO
Primary
Human, Murine, Rat
Immunofluorescence, Western Blot
250μg/mL
Affinity Purified
Human DBP2 aa. 256-366
50μg
Cell Biology
Monoclonal
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