DCAMKL2 Mouse anti-Human, Clone: 2A5, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA523144
Peptide Sequence: FRGLKISAHG RSSSNVNGGP ELDRCISPEG VNGNRCSESS TLLEKYKIGK VIGDGNFAVV KECIDRSTGK EFALKIIDKA KCCGKEHLIE *DCLK2 is one of three doublecortin-like kinases similar to the Ca2+/calmodulin-dependent protein kinase (CaMK) family. DCLK2 mRNA, like that of the homologous DCLK1 and DCLK3, is highly expressed in adult brain, but only DCLK1 and DCLK2 transcripts are present in human fetal brain and the developing mouse embryo, suggesting that DCLK1 and DCLK2 may play roles in cortical development. The DCLK proteins are homologous to Doublecortin (DCX), a protein that is mutated in X-linked human lissencephaly. In mouse models where the DCX gene has been disrupted, DCLK1 expression increases slightly and appears to compensate for the loss of DCX, as mice mutant for both DCX and DCLK1 show a severe phenotype including perinatal lethality, disorganized neocortical layering, and profound hippocampal cytoarchitectural disorganization. Unlike DCLK1, DCLK2 expression does not change in DCX-null mice.
|PBS with no preservative; pH 7.4|
|CL2, CLICK-II, CLICK2, CLIK2, DCAMKL2, DCDC3, DCDC3B, DCK2; CaMK-like CREB regulatory kinase 2; doublecortin and CaM kinase-like 2; doublecortin domain-containing protein 3B; doublecortin-like and CAM kinase-like 2; serine/threonine-protein kinase DCLK2|
|-20° C, Avoid Freeze/Thaw Cycles|
|ELISA, Western Blot|
|DCLK2 (AAH32726, 348 a.a. ∽ 438 a.a) partial recombit protein with GST tag. MW of the GST tag alone is 26 KDa.|
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