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DCC Mouse anti-Human, Clone: 531505, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA524233

Catalog No. PIMA524233


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Description

Description

This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
Specifications

Specifications

DCC
Monoclonal
Unconjugated
DCC
Lyophilized
DCC
E. coli-derived recombit human DCC Ser1323-Phe1447
Protein A/G
RUO
Antibody
Monoclonal
Human
Immunohistochemistry (Paraffin)
531505
PBS with no preservative
P43146
CRC18, CRCR1, IGDCC1
Mouse
IgG2B
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
1630
Documents
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