DCLK3 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520911
A suggested positive control is K562 cell lysate. PA5-20911 can be used with blocking peptide PEP-1025.DCLK3 is one of three doublecortin-like kinases similar to the Ca2+/calmodulin-dependent protein kinase (CaMK) family. DCLK3 mRNA, like that of the homologous DCLK1 and DCLK3, is highly expressed in adult brain, but only DCLK3 transcripts are present in liver and kidney, suggesting that DCLK3 may play other roles than in cortical development. The DCLK proteins are homologous to Doublecortin (DCX), a protein that is mutated in X-linked human lissencephaly. In mouse models where the DCX gene has been disrupted, DCLK1 expression increases slightly and appears to compensate for the loss of DCX, as mice mutant for both DCX and DCLK1 show a severe phenotype including perinatal lethality, disorganized neocortical layering, and profound hippocampal cytoarchitectural disorganization.
|A 14 amino acid peptide near the amino terminus of human DCLK3.|
|Antigen affinity chromatography|
|Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|hCG_16695, CLR, DCAMKL3, DCDC3C, DCK3; CLICK-I,II-related; doublecortin and CaM kinase-like 3; doublecortin domain-containing protein 3C; doublecortin-like and CAM kinase-like 3; serine/threonine-protein kinase DCLK3|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
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