CD263 (TRAIL-R3) Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA129165
PA1-29165 detects DcR1 from human samples. PA1-29165 has been successfully used in immunohistochemistry (paraffin tissue) applications. The PA1-29165 immunogen is: Synthetic peptide corresponding to the N-terminal extracellular domain of human DcR1 precursor protein. Positive Control: PlacentaTRAIL-R3 (CD263) is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL.
|Synthetic peptide corresponding to the N-terminal extracellular domain of human DcR1 precursor protein|
|10mM PBS with 0.2% BSA and 0.1% sodium azide; pH 7.4|
|CD263, DCR1, LIT, MGC149501, MGC149502, TRAILR3, TRID|
|4° C, do not freeze|