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MCK10 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA130315

Catalog No. PA130315


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Description

Description

PA1-30315 detects DDR1 from human samples. PA1-30315 has been successfully used in Western blot applications. Detects a band at approximately 100 kDa (predicted molecular weight of 105 kDa). Positive control of placenta lysate suggested. The PA1-30315 immunogen is a synthetic peptide conjugated to KLH, corresponding to amino acids 31-47 of Human DDR1. Store at 4°C short term. For extended storage, aliquot and store at -20°C or below. Avoid freeze/thaw cycles.

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants.
Specifications

Specifications

MCK10
Polyclonal
Unconjugated
DDR1
Liquid
DDR1
Synthetic peptide conjugated to KLH, corresponding to amino acids 31-47 of Human DDR1.
Protein G
RUO
Antibody
Polyclonal
Human
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
0.25-0.5 mg/mL
PBS with 0.09% sodium azide
Q08345
DAAP-278B20.1, CAK, CD167, DDR, EDDR1, MCK10, NEP, NTRK4, PTK3, PTK3A, RTK6, TRKE, CD167a
Rabbit
IgG
400 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
780
Documents
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