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MCK10 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA514177

Catalog No. PIPA514177


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Description

Description

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. DDR1 is an RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. It belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis show that expression of DDR1 is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain.
Specifications

Specifications

MCK10
Polyclonal
Unconjugated
DDR1
Liquid
DDR1
KLH conjugated synthetic peptide between 299-330 amino acids from the central region of human DDR1
Protein A, Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
2.0 mg/mL
PBS with 0.09% sodium azide
Q08345
DAAP-278B20.1, CAK, CD167, DDR, EDDR1, MCK10, NEP, NTRK4, PTK3, PTK3A, RTK6, TRKE, CD167a
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
780
Documents
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