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DDR2 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA527752

Catalog No. PIPA527752


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Description

Description

PA5-27752 targets DDR2 in IHC (P) and WB applications and shows reactivity with Human and mouse samples. The PA5-27752 immunogen is recombit fragment corresponding to a region within amino acids 628 and 855 of Human DDR2. Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5 ft. UTR results in multiple transcript variants encoding the same protein.
Specifications

Specifications

DDR2
Polyclonal
Unconjugated
DDR2
Liquid
DDR2
Recombit fragment corresponding to a region within amino acids 628 and 855 of Human DDR2
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunohistochemistry (Paraffin), Western Blot
1.09 mg/mL
PBS with 20% glycerol and 0.025% Proclin 300; pH 7
Q16832, Q62371
MIG20a, NTRKR3, TKT, TYRO10, CD167 antigen-like family member B, cell migration-inducing protein 20, discoidin domain receptor 2, discoidin domain receptor family, member 2, discoidin domain-containing receptor 2, discoidin domain-containing receptor tyrosine kinase 2, hydroxyaryl-protein
Rabbit
IgG
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
18214, 4921
Documents
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