DDX1 Mouse anti-Human, Unlabeled, Clone: 22, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 611206
DEAD box proteins, a family of putative RNA helicases, are characterized by eight conserved amino acid motifs that are arranged in a core region as found in the prototypical member of the family, eIF-4A. The family's name is derived from the amino acid sequence Asp-Glu-Ala-Asp (DEAD) that is located within the ATP hydrolysis motif. DEAD box proteins have been implicated in translation initiation and RNA splicing, degradation, and stability. The DEAD box protein, DDX1, was identified in retinoblastoma cell lines, where it is coamplified with MYCN, a member of the MYC transcription factor family. DDX1 is expressed at elevated levels in fetal tissues of neural origin (retina and brain). It is both cytoplasmic and nuclear in DDX1-amplified neuroblastoma and retinoblastoma cell lines. However, it localizes specifically to the nucleus in non-amplified cell lines. Thus, DDX1 is thought to be involved in nuclear RNA metabolism. In addition, the decrease in mean disease-free survival of neuroblastoma patients exhibiting coamplification of DDX1 and MYCN as compared to those exhibiting MYCN amplification indicates a possible role for DDX1 in cancer formation in neural tissues.
Host Species: Mouse
Species Reactivity: Human
Immunogen: Human DDX1 aa. 351-544
Formula Weight [Chemical]: 82kDa
Immunofluorescence, Western Blotting
|Human DDX1 aa. 351-544|
|Immunofluorescence, Western Blot|
|Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.|
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