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Decorin Rabbit anti-Bovine, Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA11744

Catalog No. PA1-1744


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Description

Description

PA1-1744 detects human, mouse, and bovine decorin neoepitope. PA1-1744 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~22 kDa protein representing the decorin fragment generated by digestion of human decorin with MMP-3. The PA1-1744 immunizing peptide is a synthetic peptide corresponding to residues C G G P K T L Q E of human Decorin Neo.

Decorin is a member of the small, leucine-rich proteoglycan (SLRP) family along with biglycan. Found in the interterritorial region of cartilage, decorin interacts with collagen and other matrix proteins to regulate the cartilaginous matrix. It has been shown to interact with fibronectin, thrombospondin, C1q, epidermal growth factor receptor (EGFR), and TGF-b. It is believed that decorin also plays a role in the cell cycle of chondrocytes. The decorin neoepitope fragment has a sequence of PKTLQE, and is generated by MMP-3 or ADAMTS-4 cleavage at Glu154-Leu155 of decorin core protein.
Specifications

Specifications

Decorin
Polyclonal
Unconjugated
DCN
Liquid
DCN
Synthetic peptide corresponding to residues C G G P K T L Q E of human Decorin Neo.
Affinity chromatography
RUO
Antibody
Polyclonal
Bovine, Human, Mouse
Western Blot
0.5 mg/mL
PBS with 1mg/mL BSA and 0.05% sodium azide
P21793, P07585, P28654
CSCD, DSPG2, PG40, PGII, PGS2, SLRR1B
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
13179, 1634, 280760
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