Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

DEDD2 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA522807

Catalog No. PIPA522807


Add to cart

Description

Description

Suggested positive control: antigen standard for DEDD2 (transient overexpression lysate).

Apoptotic signals are often triggered by cell surface death receptors through protein-protein interactions mediated by conserved domains such as the death effector domain. A novel death effector domain (DED)-containing protein, DEDD2, has been recently identified. Over-expression of DEDD2 in transfected cells induces moderate apoptosis and results in substantial sensitization to apoptosis induced by Fas, TRAIL, and FADD. More recently, it has been shown that DEDD2 can bind caspase-8 and -10 in addition to FLIP but not FADD. Like the related protein DEDD, DEDD2 translocates from the cytosol to the nucleus upon induction of apoptosis, and it has been suggested that DEDD2 may target caspase-8 to the nucleus and that DEDD2 thus plays a critical role in death receptor-induced apoptosis. At least two alternatively spliced transcript variants encoding distinct isoforms have been found for DEDD2.
Specifications

Specifications

DEDD2
Polyclonal
whole serum with 0.02% sodium azide
Q8WXF8
PSEC0004, FLAME-3, DED-containing protein FLAME-3, DNA-binding death effector domain-containing protein 2, FADD-like anti-apoptotic molecule 3, death effector domain-containing DNA binding protein 2
Rabbit
IgG
RUO
Antibody
Polyclonal
Human
Western Blot
Unconjugated
DEDD2
Liquid
DEDD2
Synthetic peptide corresponding to residues 144-129 of the DEDD2 protein.
100 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
162989
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit