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Delta-Like Protein 4 Mouse anti-Human, Unlabeled, Clone: MHD4-46, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 564589

Catalog No. BDB564589


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Description

Description

The MHD4-46 monoclonal antibody specifically binds to Delta-Like Protein 4 which is also known as Delta4, DLL4, and DL4. Delta-Like Protein 4 is a type 1 transmembrane glycoprotein which belongs to the Delta/Serrate/Jagged Family of Notch receptor ligands. The Notch family of transmembrane receptors and their ligands play key roles in various developmental and postnatal processes by controlling cell-fate decisions. Delta-Like Protein 4 is expressed by vascular endothelial cells within certain normal tissues and tumors. It signals through Notch1 and Notch 4 Receptors and plays a critical role in vascular development and homeostasis. Delta-Like Protein 4 expression is upregulated in response to vascular endothelial growth factor (VEGF) and regulates endothelial cell proliferation during vascular sprouting. Delta-Like Protein 4 is also expressed by activated human monocytes and dendritic cells that have been stimulated with proinflammatory activators such as lipopolysaccharide. Recent evidence suggests that Delta-Like Protein 4 may contribute to the T cell potential of CD34+ cells and to the growth of various tumors, and promote tumor cell infiltration.

During product development, the specificity of the purified MHD4-46 antibody was confirmed by immunohistochemical staining of acetone-fixed frozen sections of human placenta. Vascular endothelial cells were specifically stained.

Specifications

Specifications

Delta-Like Protein 4
MHD4-46
Unconjugated
Aqueous buffered solution containing ≤0.09% sodium azide.
Murine
IgG1, κ
0.1mg
Store undiluted at 4°C
Monoclonal
Flow Cytometry
0.5mg/mL
DLL4; Delta-like 4; DL4; Delta ligand 4; Delta4; Notch ligand DLL4
Affinity Purified
Human Delta-Like Protein 4 Recombinant Protein
The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
RUO
Primary
Human
Documents
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