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DEPDC6 Rabbit anti-Equine, Human, Non-human primate, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523470

Catalog No. PIPA523470


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Description

Description

DEP domain-containing mTOR-interacting protein (DEPOR/DEPTOR/DEPDC6) is a negative regulator of the mTORC1 and mTORC2 signaling pathways that regulate cell growth, proliferation and survival. It has two DEP domains and a PDZ (DHR) domain. Loss of DEPTOR activates S6K1, Akt, and SGK1, promotes cell growth and survival, and activates mTORC1 and mTORC2 kinase activities. DEPTOR overexpression suppresses S6K1 but, by relieving feedback inhibition from mTORC1 to PI3K signaling, activates Akt. Consistent with many human cancers having activated mTORC1 and mTORC2 pathways, DEPTOR expression is low in most cancers. Surprisingly, DEPTOR is highly overexpressed in a subset of multiple myelomas harboring cyclin D1/D3 or c-MAF/MAFB translocations. In these cells, high DEPTOR expression is necessary to maintain PI3K and Akt activation and a reduction in DEPTOR levels leads to apoptosis. It has also been reported that DEPOR has some functional significance in Lipid Biosynthesis.
Specifications

Specifications

DEPDC6
Polyclonal
Unconjugated
DEPTOR
Liquid
DEPTOR
Synthetic peptide (243 DSPFCLRKQSHDNRKS 258) of DEPOR/DEPDC6 protein.
Protein A
RUO
Antibody
Polyclonal
Equine, Human, Non-human Primate, Rat
Western Blot
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
Q8TB45
DEP.6, DEPDC6, DEP domain containing 6, DEP domain containing mTOR interacting protein, DEP domain-containing mTOR-interacting protein, DEP domain-containing protein 6
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
100057185, 314979, 64798
Documents
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