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Desmin Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA137555

Catalog No. 01-673-362


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Description

Description

This antibody is predicted to react with mouse and rat based on sequence homology. A suggested positive control is skeletal muscle or sarcoma.

Desmin is a 53 kDa intermediate filament protein expressed in cardiac, skeletal, and smooth muscle cells, as well as lung tissue. In skeletal and cardiac muscle cells, desmin is localized at the Z-disk region and the intercalated disk. In smooth muscle tissue, desmin is expressed throughout the cells. During development, levels of desmin expression vary, being present at low levels in the early stages of myoblast replication and increasing during terminal differentiation. Unlike vimentin, desmin is expressed in both differentiating and mature muscle cells. Inhibiting desmin expression blocks myoblast fusion and myotube formation, suggesting that desmin is crucial during myogenesis.
Specifications

Specifications

Desmin
Polyclonal
TBS with 1% BSA and 0.099% sodium azide; pH 7.6
P17661
CMD1I, CSM2, DES, FLJ12025
Rabbit
IgG
7 mL
4° C, do not freeze
Primary
1674
Immunohistochemistry (Paraffin)
Unconjugated
DES
Liquid
DES
Synthetic peptide mapping near the C-terminus of human desmin
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
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