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Desmin Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA137556

Catalog No. 01-673-363

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Desmin is a 53kDa intermediate filament protein expressed in cardiac, skeletal, and smooth muscle cells, as well as lung tissue. In skeletal and cardiac muscle cells, desmin is localized at the Z-disk region and the intercalated disk. In smooth muscle tissue, desmin is expressed throughout the cells. During development, levels of desmin expression vary, being present at low levels in the early stages of myoblast replication and increasing during terminal differentiation. Unlike vimentin, desmin is expressed in both differentiating and mature muscle cells. Inhibiting desmin expression blocks myoblast fusion and myotube formation, suggesting that desmin is crucial during myogenesis.

This antibody is predicted to react with bovine, chicken, canine, amphibian, porcine, rabbit and rat based on sequence homology.A suggested positive control is skeletal muscle or sarcoma.
Specifications

Specifications

Desmin
Polyclonal
PBS with 1% BSA and 0.1% sodium azide; pH 7.6
P17661, P31001
CMD1I, CSM2, DES, FLJ12025
Rabbit
IgG
1 mL
-20° C, Avoid Freeze/Thaw Cycles
Primary
13346, 1674
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)
Unconjugated
DES
Liquid
DES
Synthetic peptide mapping near the C-terminus of human desmin
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Documents
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