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DFFB Mouse anti-Human, Clone: 36A349, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA141140

Catalog No. 01-676-475


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Description

Description

Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A mouse DNase that causes DNA fragmentation was identified recently and designated CAD (for caspase activated deoxyribonuclease). The human homologue of mouse CAD was more recently identified by two groups independently and termed CPAN and DFF40. Human DFF45 and its mouse homologue ICAD are the inhibitors of CPAN/DFF40 and CAD, respectively. Upon cleavage of DFF45/ICAD by activated caspase, DFF40/CAD is released and activated and eventually causes the degradation of DNA in the nuclei. Activation of CAD/DFF40, which causes DNA degradation, is the hallmark of apoptotic cell death.
Specifications

Specifications

DFFB
Monoclonal
0.5 mg/mL
PBS with 0.02% sodium azide
O76075
CAD,CPAN
Mouse
IgG1
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
1677
Western Blot
36A349
Unconjugated
DFFB
Liquid
DFFB
Synthetic peptide corresponding to residues 205-222 of human DFF40.
Protein G
RUO
Antibody
Monoclonal
Human
Documents
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