ICAD Rabbit anti-Mouse, Polyclonal, Invitrogen™

Catalog No.	Quantity
PIPA129166	500 μL

Catalog No. PIPA129166

Supplier: Thermo Scientific PA129166

Description

Rabbit Polyclonal Antibody

PA1-29167 detects ERK2 from mouse, rat, human samples. PA1-29167 has been successfully used in Western blot applications. The PA1-29167 immunogen is: Synthetic peptide corresponding to the N-terminus of human Erk2 protein.

ICAD is the inhibitor of caspase-3-activated DNase which is a substrate that controls nuclear apoptosis. ICAD has two isoforms: a functional isoform of 45kDa, ICAD-L/DNA fragmentation factor (DFF) 45; and a 35kDa isoform, ICAD-S/DFF35. Although both ICAD-L and ICAD-S can bind and inhibit CAD, only ICAD-L was reported to be functional. ICAD is cleaved to be inactivated and allow caspase-activated DNase (CAD) to execute nuclear internucleosomal apoptotic DNA fragmentation. In non-apoptotic cells, CAD is complexed with its inhibitor, ICAD. The activation of the CAD/ICAD complex occurs through the caspase 3-mediated cleavage of ICAD at residues 117 and 224, which results in three ICAD fragments that are then released from CAD. In addition to its DNase inhibitory activity, ICAD acts as a CAD specific folding chaperone. There are recent reports that ICAD is a potential target for restoring a normal apoptotic signal transduction pathway in colon and brain cancer cells. Two alternatively spliced transcript variants encoding distinct isoforms have been found for the ICAD gene.

Specifications

• Antigen: ICAD
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Gene: Dffa
• Gene Accession No.: O54786
• Gene Alias: RP23-121D17.3, A330085O09Rik, DFF35, Dff45, ICAD, ICAD-L, ICAD-S
• Gene Symbols: DFFA
• Host Species: Rabbit
• Immunogen: Synthetic peptide - near the C terminus of mouse DFF45/ICAD
• Purification Method: Protein A
• Quantity: 500 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 13347
• Target Species: Mouse
• Content And Storage: 4° C, do not freeze
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG