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DGAT1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA116985
This antibody is not applicable for IHC-paraffin embedded sections. Suggested positive control: HepG2 lysate.Glucose and insulin are anabolic signals which upregulate the transcriptions of a series of lipogenic enzymes to convert excess carbohydrate into triglycerides for efficient energy storage. DGAT1 is a microsomal enzyme that assists in the synthesis of fatty acids into triglycerides. DGAT catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol (DAG) and fatty acyl CoA as substrates. DGAT plays a fundamental role in the metabolism of cellular diacylglycerol and is important in higher eukaryotes for physiologic processes involving triacylglycerol metabolism such as intestinal fat absorption, lipoprotein assembly, adipose tissue formation, and lactation. DGAT1 is involved in fat absorption in the intestine and in basal level triglyceride synthesis in adipose tissue, where it is more highly expressed.
|Synthetic peptide corresponding to residues 200-300 of human DGAT1.|
|Antigen affinity chromatography|
|Human, Mouse, Rat, Zebrafish|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|PBS with 0.05% sodium azide|
|Q8MK44, O75907, Q9Z2A7, Q9ERM3|
|Acyl coenzyme A, Diacylglycerol O-acyltransferase 1, EC 184.108.40.206, Diglyceride acyltransferase, ACT-related gene product 1|
|-20° C, Avoid Freeze/Thaw Cycles|
|13350, 282609, 325875, 84497, 8694|
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