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LGP2 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA525344

Catalog No. PIPA525344


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Description

Description

Anti-viral innate immune responses are triggered by pathogen-associated molecular patters (such as the accumulation of intracellular nucleic acids resulting from virus infections) and represent the first line of defense against numerous infectious organisms. The Toll-like receptors (TLR) 3, 7, 8, and 9 are expressed in immune cells and function as transmembrane pattern recognition receptors to detect foreign nucleic acids. Other proteins that play similar roles, such as RIG-1 and MDA5 are members of a CARD-helicase family and are expressed in the cytoplasm. A third protein, LGP2, is similar to RIG-1 and MDA5, except for lacking a homologous CARD domain. It is thought to act as an element of negative-feedback regulation of intracellular antiviral signaling. At least four isoforms of LGP2 are known to exist.
Specifications

Specifications

LGP2
Polyclonal
PBS with 0.09% sodium azide
Q96C10
D11LGP2, D11lgp2e, LGP2, RIG-I-like receptor LGP2, RLR, RNA helicase LGP2, ortholog of mouse D11lgp2, probable ATP-dependent RNA helicase DHX58, probable ATP-dependent helicase LGP2, protein D11Lgp2 homolog
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
79132
Immunohistochemistry, Western Blot
Unconjugated
DHX58
Liquid
DHX58
KLH conjugated synthetic peptide between 41-69 amino acids from the N-terminal region of human DHX58
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
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