LGP2 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA525344
DescriptionAnti-viral innate immune responses are triggered by pathogen-associated molecular patters (such as the accumulation of intracellular nucleic acids resulting from virus infections) and represent the first line of defense against numerous infectious organisms. The Toll-like receptors (TLR) 3, 7, 8, and 9 are expressed in immune cells and function as transmembrane pattern recognition receptors to detect foreign nucleic acids. Other proteins that play similar roles, such as RIG-1 and MDA5 are members of a CARD-helicase family and are expressed in the cytoplasm. A third protein, LGP2, is similar to RIG-1 and MDA5, except for lacking a homologous CARD domain. It is thought to act as an element of negative-feedback regulation of intracellular antiviral signaling. At least four isoforms of LGP2 are known to exist.
|PBS with 0.09% sodium azide|
|D11LGP2, D11lgp2e, LGP2, RIG-I-like receptor LGP2, RLR, RNA helicase LGP2, ortholog of mouse D11lgp2, probable ATP-dependent RNA helicase DHX58, probable ATP-dependent helicase LGP2, protein D11Lgp2 homolog|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry, Western Blot|
|KLH conjugated synthetic peptide between 41-69 amino acids from the N-terminal region of human DHX58|
|Antigen affinity chromatography|
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