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Dicer Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523088

Catalog No. PIPA523088


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Description

Description

Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.

DICER1 is a ribonuclease that has been extensively shown to be related to cancer. Small interfering RNAs are generated through DICER, and seem to play important roles in mitosis in normal cells and oncogenesis in mutated cells. DICER1 mutations are associated with blastoma, breast cancer, adenocarcinoma, and pancreatitis. In vision and hearing, DICER1 has been implicated in serious microRNA induced malformations of critical sensory cells. DICER1 is important in myelination and other nervous system protections. Finally, DICER1 is related to cardiovascular diseases, since microRNAs are aberrantly expressed in some pathological conditions.
Specifications

Specifications

Dicer
Polyclonal
Unconjugated
DICER1
Liquid
DICER1
A synthetic peptide made to an internal region of the human DICER1 protein (within residues 1100-1300).
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin)
0.56 mg/mL
PBS with 0.1% BSA, 50% glycerol and 0.05% sodium azide
Q9UPY3, Q8R418
DCR1, Dicer, HERNA, MNG1, Dicer1, Dcr-1 homolog, K12H4.8-LIKE, dicer 1, double-stranded RNA-specific endoribonuclease, endoribonuclease Dicer, helicase MOI, helicase with RNAse motif, helicase-moi
Rabbit
IgG
50 μL
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
192119, 23405
Documents
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