DIO3 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA526537
DescriptionDIO3 belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3 ft.,5-triiodothyronine (T3) to inactive metabolites, 3,3 ft.,5 ft.-triiodothyronine (RT3) and 3,3 ft.-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregt uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3 ft. UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.
|KLH conjugated synthetic peptide between 250-278 amino acids from the C-terminal region of human DIO3|
|Antigen affinity chromatography|
|Immunohistochemistry (Paraffin), Western Blot|
|PBS with 0.09% sodium azide|
|5DIII, D3, DIOIII, TXDI3, iodothyronine deiodinase, placental type, thyroxine deiodinase type III (selenoprotein), type 3 DI, type 3 iodothyronine selenodeiodinase, type III iodothyronine deiodinase, type-III 5′ deiodinase, type-III 5′-deiodinase|
|-20° C, Avoid Freeze/Thaw Cycles|
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