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Diphtheria Toxin Goat anti-Bacteria, Polyclonal, Invitrogen™

Goat Polyclonal Antibody

Manufacturer:  Invitrogen PA17212

Catalog No. PA17212


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Description

Description

PA1-7212 detects diphtheria toxin. PA1-7212 has been successfully used in ELISA procedures. The PA1-7212 immunogen is purified diphtheria toxoid. For longer term storage, aliquot and freeze at -20°C.

Diphtheria toxin is a 58 kDa protein secreted by lysogenic strains of Corynebacterium diphtheriae. The toxin causes the disease diphtheria in humans by gaining entry into the cell cytoplasm and inhibiting protein synthesis. The mechanism of inhibition involves transfer of the ADP-ribose group of NAD to elongation factor-2 (EF-2), rendering EF-2 inactive. The catalysed reaction is as follows: NAD + + peptide diphthamide = nicotinamide + peptide N-(ADP-D-ribosyl)diphthamide The crystal structure of the diphtheria toxin homodimer has been determined to 2.5A resolution. The structure reveals a Y-shaped molecule of 3 domains, a catalytic domain (fragment A), whose fold is of the alpha + beta type; a transmembrane (TM) domain, which consists of 9 alpha-helices, 2 pairs of which may participate in pH-triggered membrane insertion and translocation; and a receptor-binding domain, which forms a flattened beta-barrel with a jelly-roll-like topology. The TM- and receptor binding-domains together constitute fragment B.
Specifications

Specifications

Diphtheria Toxin
Polyclonal
Unconjugated
Liquid
Goat
IgG
1 mL
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C
Primary
Bacteria
ELISA
4-5 mg/mL
PBS with 0.1% sodium azide; pH 7.2
DT
Purified diphtheria toxoid.
Purified
RUO
Antibody
Polyclonal
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