DLL4 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA186897
Predicted to react with chimpanzee, mouse and rat based on sequence homology. A suggested positive control for immunohistochemical applications is human ovary. In Western blot, this antibody detects a band at ~74 kDa in pancreatic cell lysate. Rabbit anti Human Delta-like Protein 4 antibody detects human Delta-like protein 4 (DLL4), also known as Delta-4.Delta-like ligand 4 (DLL4), also know as Delta-4, is a homologue of the Drosophila delta protein, and functions as a transmembrane bound ligand to the notch receptor Notch1. DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF), as a negative feedback regulator to regulate angiogenic sprouting and promote the formulation of a differentiated vascular network. DLL4 has been found to be strongly expressed in tumor vessels of clear-cell renal tumors and bladder cancer, and inhibition of DLL4 results in increased vascular proliferation but defective maturation. This in turn leads to a decrease in tumor growth, with no apparent toxicity.
|Synthetic peptide corresponding to the internal region of human DLL4.|
|ELISA, Immunohistochemistry (Paraffin), Western Blot|
|PBS with 0.09% sodium azide|
|4°C or -20°C if preferred|
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