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DLL4 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA186897

Catalog No. PA186897


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Description

Description

Predicted to react with chimpanzee, mouse and rat based on sequence homology. A suggested positive control for immunohistochemical applications is human ovary. In Western blot, this antibody detects a band at ~74 kDa in pancreatic cell lysate. Rabbit anti Human Delta-like Protein 4 antibody detects human Delta-like protein 4 (DLL4), also known as Delta-4.

Delta-like ligand 4 (DLL4), also know as Delta-4, is a homologue of the Drosophila delta protein, and functions as a transmembrane bound ligand to the notch receptor Notch1. DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF), as a negative feedback regulator to regulate angiogenic sprouting and promote the formulation of a differentiated vascular network. DLL4 has been found to be strongly expressed in tumor vessels of clear-cell renal tumors and bladder cancer, and inhibition of DLL4 results in increased vascular proliferation but defective maturation. This in turn leads to a decrease in tumor growth, with no apparent toxicity.
Specifications

Specifications

DLL4
Polyclonal
Unconjugated
DLL4
Liquid
DLL4
Synthetic peptide corresponding to the internal region of human DLL4.
Affinity chromatography
RUO
Antibody
Polyclonal
Human
ELISA, Immunohistochemistry (Paraffin), Western Blot
0.5 mg/mL
PBS with 0.09% sodium azide
Q9NR61
MGC126344, hdelta2
Rabbit
IgG
50 μg
4°C or -20°C if preferred
Primary
54567
Documents
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