DNMT3A Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA1882
PA1-882 detects DNA methyltransferase 3a (Dnmt3a) from human and mouse tissues and cells as well as recombit human Dnmt3a. This antibody does not detect full length recombit human Dnmt3b or Dnmt1. PA1-882 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~120 kDa protein representing Dnmt3a from P19 cell nuclear extracts. The PA1-882 immunogen is a synthetic peptide corresponding to residues D(86) L L P N G D L E K R S E P Q(100) C of human Dnmt3a. This immunizing peptide (Cat. No. PEP-116) is available for use in neutralization and control experiments.DNA methyltransferases methylate the 5-position of cytosine in the context of CpG dinucleotides. DNA methylation is crucial for normal embryonic development, genetic imprinting, and X-chromosome inactivation. Hypermethylation of DNA has also been implicated in tumorigenesis through improper methylation of growth regulatory gene promoter regions.
|Synthetic peptide corresponding to residues D(86) L L P N G D L E K R S E P Q(100) C of human Dnmt3a.|
|Antigen affinity chromatography|
|PBS with 1mg/mL BSA and 0.05% sodium azide|
|-20° C, Avoid Freeze/Thaw Cycles|
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