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DNA Polymerase ε catalytic Mouse anti-Human, Unlabeled, Clone: 34, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 611238

Catalog No. BDB611238

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

Damaged or erroneous DNA may result from the effects of environmental factors or synthesis errors committed by DNA polymerases during replication. If unchecked, these errors might accumulate genetic damage such that the cell could no longer properly function. Thus, DNA repair processes involve mechanisms for the excision of damaged sequences and the resynthesis and ligation of the proper sequence. DNA polymerase ε functions in DNA replication and repair. It consists of a large catalytic subunit, reportedly ranging in size from 220 kDa to 261kDa, and a 55kDa small subunit that is thought to function as an adaptor between the catalytic subunit and accessory proteins such as DPB2, DPB3, and proliferating cell nuclear antigen (PCNA). The polymerase and proofreading exonuclease activities are located in the N-terminal portion of the catalytic subunit. Although the C-terminal portion contains a putative Zn2+ finger DNA-binding domain, the function of this region is not required for enzyme activity. The interaction of DNA Pol ε with PCNA promotes primer recognition and DNA synthesis. Thus, DNA Pol ε is essential for DNA replication and the maintenance of accurate DNA sequence, which ensures cellular function and viability.

Host Species: Mouse
Clone: 34
Isotype: IgG2b
Species Reactivity: Human
Immunogen: Human DNA Polymerase ε catalytic aa. 629-749
Formula Weight [Chemical]: 220kDa

Immunofluorescence, Western Blotting

Specifications

Specifications

DNA Polymerase ε catalytic
34
Unconjugated
Murine
IgG2b
RUO
Primary
Human
Immunofluorescence, Western Blot
250μg/mL
Affinity Purified
Human DNA Polymerase ε catalytic aa. 629-749
50μg
Cell Biology
Monoclonal
Documents
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