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POLG Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA121791

Catalog No. PA121791

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

PA1-21796 detects VEGF in Human, Rat and Mouse samples. PA1-21796 has been successfully used in Immunohistochemistry (Paraffin) procedures. Staining of formalin fixed tissues requires boiling tissue sections in 10 mM Tris-HCl, pH 10.0, for 10-20 minutes

As the only DNA polymerase (pol) present in mitochondria, DNA polymerase gamma (POLG) is necessarily implicated in base excision repair processes to correct oxidative damage to the mitochondrial genome. Therefore, the ability of the catalytic subunit of human POLG has been tested to participate in uracil provoked base excision repair reconstituted in vitro with purified components. Subsequent to actions of uracil DNA glycosylase and apurinic/apyrimidinic endonuclease, human POLG is able to fill a single nucleotide gap in the presence of a 5 ft. terminal deoxyribose phosphate (dRP) flap. The catalytic subunit of human pol gamma catalyzes release of the dRP residue from incised apurinic/apyrimidinic sites to produce a substrate for DNA ligase. Faulty replication of the human mitochondrial genome is thought to be the cause of many diseases. The low selectivity of the mitochondrial DNA polymerase is implicated as the cause of many side effects observed in the treatment of viral infections such as HIV.
Specifications

Specifications

POLG
Polyclonal
Unconjugated
POLG
Liquid
POLG
Purified native human recombit amino acids 714 - 1061 DNA polymerase gamma.
Protein A
RUO
Antibody
Polyclonal
Human
Western Blot
0.2 mg/mL
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
P54098
FLJ27114, MDP1, PEO, POLG1, POLGA, SANDO, SCAE
Rabbit
IgG
500 μL
4° C, do not freeze
Primary
5428
Documents
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