POLG Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA121791
PA1-21796 detects VEGF in Human, Rat and Mouse samples. PA1-21796 has been successfully used in Immunohistochemistry (Paraffin) procedures. Staining of formalin fixed tissues requires boiling tissue sections in 10 mM Tris-HCl, pH 10.0, for 10-20 minutesAs the only DNA polymerase (pol) present in mitochondria, DNA polymerase gamma (POLG) is necessarily implicated in base excision repair processes to correct oxidative damage to the mitochondrial genome. Therefore, the ability of the catalytic subunit of human POLG has been tested to participate in uracil provoked base excision repair reconstituted in vitro with purified components. Subsequent to actions of uracil DNA glycosylase and apurinic/apyrimidinic endonuclease, human POLG is able to fill a single nucleotide gap in the presence of a 5 ft. terminal deoxyribose phosphate (dRP) flap. The catalytic subunit of human pol gamma catalyzes release of the dRP residue from incised apurinic/apyrimidinic sites to produce a substrate for DNA ligase. Faulty replication of the human mitochondrial genome is thought to be the cause of many diseases. The low selectivity of the mitochondrial DNA polymerase is implicated as the cause of many side effects observed in the treatment of viral infections such as HIV.
|Purified native human recombit amino acids 714 - 1061 DNA polymerase gamma.|
|PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4|
|FLJ27114, MDP1, PEO, POLG1, POLGA, SANDO, SCAE|
|4° C, do not freeze|
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