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DNAL1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520573

Catalog No. PIPA520573


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Description

Description

A suggested positive control is NIH-3T3 cell lysate. PA5-20573 can be used with blocking peptide PEP-0693.

DNAL1 was identified as a potential candidate gene for primary ciliary dyskinesia (PCD), a genetically heterologous disorder characterized by chronic infections of the upper and lower airways that often leads to permanent lung damage, randomization of left/right body symmetry, and reduced fertility. DNAL1 is reported to be expressed solely in tissues carrying motile cilia for flagella and interacts with DNAH5, a protein that when mutated has been shown to result in PCD. It has been suggested that DNAL1 serves a regulatory function for DNAH5 activity in outer dynein arms of sperm flagella, respiratory cilia, and ependymal cilia. DNAL1 has also been recently identified as an HIV dependency factor (HDF), suggesting that DNAL1 may be an important drug target in HIV treatment. At least two isoforms of DNAL1 are known to exist.
Specifications

Specifications

DNAL1
Polyclonal
Unconjugated
DNAL1
Liquid
DNAL1
A 17 amino acid peptide from near the carboxy terminus of human DNAL1.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q4LDG9, Q05A62
C14orf168, CILD16; dynein light chain 1, axonemal
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
105000, 685664, 83544
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