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DNase II Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA112504

Catalog No. 01-674-164


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Description

Description

A suggested positive control for this product is human spleen lysate.

Apoptosis is characterized by several morphological nuclear changes including chromatin condensation and nuclear fragmentation. These changes are triggered by the activation of members of caspase family, caspase activated DNase, and several novel proteins including AIF and Acinus. DNase II causes both chromatin condensation and DNA fragmentation. The genes encoding human, porcine, and murine DNase II have been cloned. The DNase II gene encodes a 40 kDa proenzyme. The mature enzyme consists of two non-identical subunits, the 32 kDa (a) and 12 kDa (b) chains, generated by proteolytic processing. Overexpression of DNase II induces chromatin condensation (3). DNase II is ubiquitously expressed in human tissues.
Specifications

Specifications

DNase II
Polyclonal
PBS with 0.02% sodium azide
O00115
DNASE2A, DNL, DNL2
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
1777
Western Blot
Unconjugated
DNASE2
Liquid
DNASE2
Synthetic peptide corresponding to residues 347-360 of human DNase II precursor.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
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