DNER Rat anti-Mouse, Clone: 298306, Invitrogen
Rat Monoclonal Antibody
Manufacturer: Invitrogen MA524008
In direct ELISAs and Western blots, no cross-reactivity with recombit human DNER is observed. Reconstitute at 0.5 mg/mL in sterile PBS.DNER (Delta-notch-like EGF-related receptor), also known as Delta-notch-like EGF repeat-containing transmembrane protein, is a neuron-specific, atypical Notch ligand expressed in dendrites and cell bodies of neurons throughout the central nervous system. DNER contains ten extracellular EGF-like domains that are highly homologous to those of the Notch ligand, Delta. In the cerebellum, DNER is predomitly expressed in Purkinje cells. DNER mediates neuron-glia interaction during astrocytogenesis through a direct interaction with Notch 1 at Purkinje cell/Bergmann glia contacts. This interaction activates a Deltex-dependent Notch signaling pathway in Bergmann glia and may regulate Bergmann glial morphogenesis. DNER is crucial for the functional and morphological maturation of Bergmann glia. DNER-knockout mice are characterized by motor discoordination and cerebellum retardation in morphogenesis.
|PBS with 5% trehalose and No Preservative|
|Delta and Notch-like epidermal growth factor-related receptor, DNER, BET, UNQ262/PRO299|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunohistochemistry, Western Blot|
|Mouse myeloma cell line NS0-derived recombit mouse DNER Ala26-His637|
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