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DNER Rat anti-Mouse, Clone: 298306, Invitrogen™

Rat Monoclonal Antibody

Manufacturer:  Invitrogen MA524008

Catalog No. PIMA524008


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Description

Description

In direct ELISAs and Western blots, no cross-reactivity with recombit human DNER is observed. Reconstitute at 0.5 mg/mL in sterile PBS.

DNER (Delta-notch-like EGF-related receptor), also known as Delta-notch-like EGF repeat-containing transmembrane protein, is a neuron-specific, atypical Notch ligand expressed in dendrites and cell bodies of neurons throughout the central nervous system. DNER contains ten extracellular EGF-like domains that are highly homologous to those of the Notch ligand, Delta. In the cerebellum, DNER is predomitly expressed in Purkinje cells. DNER mediates neuron-glia interaction during astrocytogenesis through a direct interaction with Notch 1 at Purkinje cell/Bergmann glia contacts. This interaction activates a Deltex-dependent Notch signaling pathway in Bergmann glia and may regulate Bergmann glial morphogenesis. DNER is crucial for the functional and morphological maturation of Bergmann glia. DNER-knockout mice are characterized by motor discoordination and cerebellum retardation in morphogenesis.
Specifications

Specifications

DNER
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
Q8JZM4
Delta and Notch-like epidermal growth factor-related receptor, DNER, BET, UNQ262/PRO299
Rat
IgG1
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
227325
Immunohistochemistry, Western Blot
298306
Unconjugated
Dner
Lyophilized
DNER
Mouse myeloma cell line NS0-derived recombit mouse DNER Ala26-His637
Protein A/G
RUO
Antibody
Monoclonal
Mouse
Documents
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